At the moment Advanced Cancer Diagnostics has offered four different tests available to patients and physicians in the UK

CNI Cancer Evaluation Test

The Chronix Biomedical CNI Cancer Evaluation Test is a screening method to detect some cancers before they are noticed by symptoms. When cancer cells die they can shed their content into the blood stream, where this material is then transported in the liquid part of the blood, the so-called blood plasma. In many cancers duplications or deletion of large sections of DNA can be detected in blood, which we use in our test. If the altered DNA concentration present in blood is high enough to detect there is the opportunity to discover a cancer before symptoms occur.

CNI Cancer Evaluation Test
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With Chronix Biomedical’s blood test we can now usefully screen asymptomatic clients when suspected being at high risk for developing cancer. This in most cases provides reassurance that all is well, however, in the event of a positive result, action can be taken and clients signposted to relevant specialists. Early detection of any cancer is vital to increasing the chance of a positive outcome.

The Chronix blood test measures CNI and gives real time risks of an individual suffering cancer. There are 3 different outcome scenarios as result of the CNI score.

1. CNI is in the healthy range. If the patient has cancer risk factors (age, gender, positive hereditary cancer mutations, smoker, etc.), then you may wish to recommend repeat testing on an annual basis.

2. A slight statistical increase in CNI has been found which correlates with a risk of early cancerous change amongst other possible explanations. It is suggested that the test is repeated in 3-6 months and, if there is a rise in the CNI score at that time, a full medical check up and scans will be recommended.

3. High CNI score. Clinical consultation and scans will be recommended.

What to do?

1If you belong to a cancer risk group, you should consult an oncologist.

You have 3 ways:

  • Use the tips in the ACD partner facility.
  • Immediately contact an authorized ACD doctor. Order the test on our website.
  • Contact your doctor in your medical facility, preferably from ACD authorized doctors list. Your doctor may contact ACD Medical Staff to discuss the test result.

2If you get a referral from your doctor, you should order a test for the risk of cancer presence (CNI Test), and then go for a blood test in one of the ACD authorized laboratories.

3Within 7-10 days of the study doctor will get your test results and discuss them with you.

IF MY CHRONIX BLOOD TEST IS POSITIVE WHAT HAPPENS NEXT?

If your blood test comes back with a positive result this result will have been seen by your consulting physician who will explain fully to you the next steps.

WHERE ARE THE CHRONIX BLOOD TESTS DONE?

The blood samples are sent to a certified Chronix Biomedical laboratory in Germany where each sample is whole genome sequenced, we are looking in particular for fragments of mutated DNA that are ejected into the blood plasma, these mutations if seen in large numbers are a fingerprint for cancer.

HOW SOON WILL I RECEIVE THE TEST RESULTS?

Test results will be ready within 7 – 10 days from the date we take your blood, and will sent directly to your Doctor.

ARE CHRONIX BIOMEDICAL TESTS SAFE?

The Chronix blood test consist of our drawing 20ml of blood into two tubes so is minimally invasive and carries no more risk than any other blood sample taken from the veins.

HOW DO I BOOK A CHRONIX BIOMEDICAL BLOOD TEST?

Complete the test enquiry form on our web site here Test Enquiry Form and one of our medical staff will contact you within 24 hours to discuss your requirements.

HOW MUCH IS A CHRONIX BIOMEDICAL BLOOD TEST?

All our tests have the same pricing structure, the first test is £2,000 and any subsequent tests are £1,500. If you have a diagnosis of cancer and are wanting either a second opinion™ or Treatment Outcome Test (Delta Dot) the cost of these tests may be reimbursable on a case by case basis by your medical insurer. Please ask one of our medical team how to proceed with reimbursement applications via your Doctor.

Second Opinion™ Prostate Cancer Evaluation Test

Second Opinion™ Prostate Cancer Evaluation Test

It has recently been found that mutated DNA fragments from cancer cells find their way into the bloodstream. They can be detected by next generation sequencing – the technique that has successfully mapped the whole human genome. Prostate cancer mutations tend to produce “hot spots” (gains and losses) in the mutated DNA fragments that are in the blood. The reasons are currently under investigation. Nonetheless, DNA from the cancer cells is detectable in your bloodstream. The Chronix Second Opinion™ prostate cancer evaluation searches for these sequences and identifies them.

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This test will supplement the information you have about test results from PSA tests or imaging enabling you to make a decision based on all the evidence to proceed to a tissue biopsy or test again at a later date.

What to do?
1If your blood test showed elevated levels of PSA, then you should consult a specialist doctor – urologist.

You have 3 ways:

  • Use the tips in the ACD partner facility.
  • Immediately contact an authorized ACD doctor. Order the test on our website.
  • Contact your doctor in your medical facility, preferably from ACD authorized doctors list. Your doctor may contact ACD Medical Staff to discuss the test result.

2If you get a referral from your doctor, you should order Prostate Cancer Test, and then go for a blood test in one of the ACD authorized laboratories.

3Within 7-10 days of the study doctor will get your test results and discuss them with you.

Prostate Explanation

Chronix Biomedical has now made available a laboratory developed test for the detection of risk factors highly associated with prostate cancer. Through the simple process of drawing blood, we can now offer a test than can with a high degree of accuracy, detect macromolecular mutations of DNA fragments in blood plasma, which are closely associated with prostate cancer.

The Chronix Biomedical Second Opinion™ Prostate Cancer Evaluation blood test was designed to be a supplemental test for men with elevated PSA.

Concerns about the PSA test

The PSA test is very sensitive. However the levels of PSA in the body often fluctuate for a variety of reasons such as physical activity, diet, medications including herbal remedies, the presence of other diseases and the age of the individual.

The PSA test is not specific for prostate cancer, indeed research has documented that given a PSA value between 4 ng/ml and 10 ng/ml only one man in four will actually have prostate cancer as definitively diagnosed by biopsy.

Given this wide disparity between PSA value and prostate cancer, and considering the cost and physical trauma involved in having a biopsy performed, it would be advantageous for the individual and healthcare system alike to have an additional blood test that could better indicate whether or not prostate cancer was present before having a biopsy performed. The Second Opinion™ Prostate Cancer Evaluation Test is a new blood supplementary test for diagnosis.

WHAT IS A PSA TEST?

The PSA test is a blood test that can detect the early signs of an enlarged prostate. It is the most common initial test for men who are worried about prostate cancer.

The test, which can be done at a GP surgery, measures the level of prostate-specific antigen (PSA) in your blood.

PSA is a protein made only by the prostate gland. Some of it will leak into your blood, and the amount depends on your age and the health of your prostate.

A raised PSA level in your blood may be a sign of prostate cancer. However, other conditions, such as an enlarged prostate, prostatitis, or a urinary infection, can also cause a raised PSA level. There are well-known issues with the accuracy of the PSA test and potential harmful consequences, which is why there is currently no national screening program for prostate cancer in the UK.

Instead, all men over the age of 50 can access quality information about the PSA test and discuss the option of having a free test with their GP as part of a scheme called the prostate cancer risk management program (PCRMP).

Under PCRMP, your GP will be expected to discuss with you the benefits, limitations, and risks of the PSA test to help you decide whether or not to have it.

 

PCRMP Guidance from Public Health England

WHAT ARE THE PROS AND CONS OF A PSA BLOOD TEST?

Pros

  • It may reassure you if the test result is normal.
  • It may give you an indication of cancer before symptoms develop.
  • It may find cancer at an early stage, when treatment could prevent the cancer becoming more advanced.
  • PSA testing may reduce your risk of dying from prostate cancer by 21%.
  • If treatment is successful, you may avoid the risks of advanced cancer.
  • In cases of advanced cancer, treatment will usually extend life.

Cons

  • It can miss cancer and provide false reassurance.
  • It may lead to unnecessary worry and medical tests when there is no cancer.
  • It cannot tell the difference between slow-growing and fast-growing cancer.
  • It may make you worry by finding slow-growing cancer that may never cause any

symptoms or shorten your life.

  • To save one life from prostate cancer, 27 men would have to be diagnosed with it.
WHAT ARE PROSTATE BIOPSIES?
  • If your PSA level is raised, a biopsy, which involves taking tissue samples from the prostate gland, may be needed to check if you have cancer.
  • Prostate biopsies can miss some cancers. One in five cancers are missed at prostate biopsy. You may not know for sure that you don’t have cancer after a clear result, and biopsies sometimes have to be repeated.
  • Biopsies can sometimes cause complications. The most common is bleeding followed by infection. Most men experience blood in the urine and blood in the sperm after a biopsy. Antibiotics will be given to prevent infections.
WHAT ARE THE STAGES OF PROSTATE CANCER?

Doctors will use the results of your prostate examination, biopsy and scans to identify the “stage” of your prostate cancer (how far the cancer has spread). The stage of the cancer will determine which types of treatments will be necessary.

A widely used method of staging is a number staging system. The stages are:

  • Stage 1 – the cancer is very small and completely within the prostate gland
  • Stage 2 – the cancer is within the prostate gland, but is larger
  • Stage 3 – the cancer has spread from the prostate and may have grown into the tubes that carry semen
  • Stage 4 – the cancer has spread into the lymph nodes or another part of the body, including the bladder, rectum or bones; about 20-30% of cases are diagnosed at this stage

If prostate cancer is diagnosed at an early stage, the chances of survival are generally good. About 90% of men diagnosed at stages 1 or 2 will live at least five more years and 65-90% will live for at least 10 more years.

If you are diagnosed with stage 3 prostate cancer, you have a 70-80% of chance of living for at least five more years.

However, if you are diagnosed when your prostate cancer has reached stage 4, there is only a 30% chance you will live for at least five more years.

WHAT IS A SECOND OPINION™ PROSTATE CANCER EVALUATION TEST?

It has recently been found that mutated DNA fragments from cancer cells find their way into the bloodstream. They can be detected by next generation sequencing–the technique that has successfully mapped the whole human genome. Prostate cancer mutations tend to produce “hot spots” (gains and losses) in the mutated DNA fragments that are in the blood.

The reasons are currently under investigation. Nonetheless, DNA from the cancer cells is detectable in your bloodstream. The Chronix Second Opinion™ prostate cancer evaluation searches for these sequences and identifies them. This test will supplement the information you have about test results from PSA tests or imaging enabling you to make a decision based on all the evidence to proceed to a tissue biopsy or test again at a later date.

IF MY CHRONIX BLOOD TEST IS POSITIVE WHAT HAPPENS NEXT?

If your blood test comes back with a positive result this result will have been seen by your consulting physician who will explain fully to you the next steps.

WHERE ARE THE CHRONIX BLOOD TESTS DONE?

The blood samples are sent to a certified Chronix Biomedical laboratory in Germany where each sample is whole genome sequenced, we are looking in particular for fragments of mutated DNA that are ejected into the blood plasma, these mutations if seen in large numbers are a fingerprint for cancer.

HOW SOON WILL I RECEIVE THE TEST RESULTS?

Test results will be ready within 7 – 10 days from the date we take your blood, and will sent directly to your Doctor.

ARE CHRONIX BIOMEDICAL TESTS SAFE?

The Chronix blood test consist of our drawing 20ml of blood into two tubes so is minimally invasive and carries no more risk than any other blood sample taken from the veins.

HOW DO I BOOK A CHRONIX BIOMEDICAL BLOOD TEST?

Complete the test enquiry form on our web site here Test Enquiry Form and one of our medical staff will contact you within 24 hours to discuss your requirements.

HOW MUCH IS A CHRONIX BIOMEDICAL BLOOD TEST?

All our tests have the same pricing structure, the first test is £2,000 and any subsequent tests are £1,500. If you have a diagnosis of cancer and are wanting either a second opinion™ or Treatment Outcome Test (Delta Dot) the cost of these tests may be reimbursable on a case by case basis by your medical insurer. Please ask one of our medical team how to proceed with reimbursement applications via your Doctor.

Second Opinion™ Breast Cancer Evaluation Test

Chronix Biomedical has made available a laboratory developed test for the detection of risk factors highly associated with Breast cancer. Through the simple process of drawing blood, we can now offer a test than can with a high degree of accuracy, detect macromolecular mutations of DNA fragments in blood plasma, which are closely associated with Breast cancer. The Chronix Biomedical Second Opinion™ Breast Cancer Evaluation blood test was designed to be a supplemental test for women with abnormal mammograms or detectable lumps.

Second Opinion™ Breast Cancer Evaluation Test
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What to do?
1In the case of irregularities breast screening (mammography or self-control), you should consult a specialist doctor – gynecologist

You have 3 ways:

  • Use the tips in the ACD partner facility.
  • Immediately contact an authorized ACD doctor. Order the test on our website.
  • Contact your doctor in your medical facility, preferably from ACD authorized doctors list. Your doctor may contact ACD Medical Staff to discuss the test result.

2If you get a referral from your doctor, you should order Breast Cancer Test, and then go for a blood test in one of the ACD authorized laboratories.

3Within 7-10 days of the study doctor will get your test results and discuss them with you.

What is Second Opinion™ Breast Cancer Evaluation Test?

It has recently been found that mutated DNA fragments from cancer cells find their way into the bloodstream. They can be detected by next generation sequencing–the technique that has successfully maps the whole human genome in the matter of hours. Breast cancer mutations tend to produce “hot spots” (gains and losses) in the mutated DNA fragments that are in the blood. The Chronix Second Opinion™ Breast cancer evaluation counts all these sequences to check for abnormalities in the count. The result is known as a copy number instability (CNI) score.

This test will supplement the information you have about test results from other diagnostics such as mammography or biopsy enabling you and your Doctor to make a decision to go to a formal tissue biopsy based on all the evidence.

WHY WOMEN SHOULD TAKE THE SECOND OPINION™ FOR BREAST CANCER?

The Chronix Biomedical Breast Cancer Second Opinion ™ test, is as an additional blood test, following either an indeterminate mammogram or biopsy or prior to biopsy to help your Doctor determine if in fact a biopsy is even needed. It is also a valuable diagnostic aid following breast surgery to assist your Doctor in determining if there is any residual disease.

HOW COMMON IS BREAST CANCER?

Breast cancer is the most common type of cancer in the UK. Most women diagnosed with breast cancer are over 50, but younger women can also get breast cancer.

About one in eight women are diagnosed with breast cancer during their lifetime. There’s a good chance of recovery if it’s detected in its early stages.

For this reason, it’s vital that women check their breasts regularly for any changes and always get any changes examined by their GP.

 

Breast Cancer Statistics 2013 Cancer Research UK

 

Cases – 53,696, Deaths – 11,433, Survival – 78%, Prevention – 27%

 

In rare cases, men can also be diagnosed with breast cancer. Read about breast cancer in men.

HOW CAN YOU PROTECT YOURSELF AGAINST BREAST CANCER?

As the causes of breast cancer aren’t fully understood, at the moment it’s not possible to know if it can be prevented.

If you’re at increased risk of developing the condition, some treatments are available to reduce the risk.

Studies have looked at the link between breast cancer and diet. Although there are no definite conclusions, there are benefits for women who:

It’s been suggested that regular exercise can reduce your risk of breast cancer by as much as a third. Regular exercise and a healthy lifestyle can also improve the outlook for people affected by breast cancer. If you’ve been through the menopause, it’s particularly important that you’re not overweight or obese.This is because being overweight or obese causes more oestrogen to be produced, which can increase the risk of breast cancer.

WHAT ARE THE RISKS AND BENEFITS OF BREAST SCREENING?

It is your choice whether or not you have breast screening. There are many different reasons why women decide whether or not to have screening. To help you decide, we’ve included information on the possible benefits and risks.

HOW DO I BECOME MORE BREAST AWARE?

The National Institute for Health and Care Excellence (NICE) says that being breast aware means:

  • knowing what’s normal for you
  • looking at your breasts and feeling them
  • knowing what changes to look for
  • reporting any changes to your doctor without delay
  • attending routine breast screening if you’re 50 or over

 

Detecting breast cancer early can mean that treatment is more effective.

Knowing what your breasts normally feel like will help you to be aware of any abnormal changes.

However, not all changes are a sign of breast cancer. Some women have cysts or thickening of the breast tissue, which is normal.

 

The Breast Cancer Care checklist

  • Look at and feel your breasts so you know what’s normal for you.
  • Do this regularly to check for changes.
  • Tell your doctor as soon as possible if you notice anything.

According to Cancer Research UK, 9 out of 10 breast lumps are not cancer.

WHAT ARE THE SYMPTOMS THAT INDICATE THE PRESENCE OF BREAST CANCER?

Be aware of the following changes in your breasts that could signal breast cancer:

  • changes in the outline or shape of the breast, especially those caused by arm movements or by lifting the breast
  • changes in the look or feel of the skin, such as puckering or dimpling
  • any new lumps, thickening or bumpy areas in one breast or armpit, with or without pain, that differs from the same part of the other breast and armpit
  • discharge from the nipple (may be bloodstained)
  • moist, red areas on the nipple that don’t heal easily
  • any change in nipple position, such as being pulled in or pointing differently
  • a rash on or around the nipple
  • If you notice any of these changes, see your GP.
IF MY CHRONIX BLOOD TEST IS POSITIVE WHAT HAPPENS NEXT?

If your blood test comes back with a positive result this result will have been seen by your consulting physician who will explain fully to you the next steps.

WHERE ARE THE CHRONIX BLOOD TESTS DONE?

The blood samples are sent to a certified Chronix Biomedical laboratory in Germany where each sample is whole genome sequenced, we are looking in particular for fragments of mutated DNA that are ejected into the blood plasma, these mutations if seen in large numbers are a fingerprint for cancer.

HOW SOON WILL I RECEIVE THE TEST RESULTS?

Test results will be ready within 7 – 10 days from the date we take your blood, and will sent directly to your Doctor.

ARE CHRONIX BIOMEDICAL TESTS SAFE?

The Chronix blood test consist of our drawing 20ml of blood into two tubes so is minimally invasive and carries no more risk than any other blood sample taken from the veins.

HOW DO I BOOK A CHRONIX BIOMEDICAL BLOOD TEST?

Complete the test enquiry form on our web site here Test Enquiry Form and one of our medical staff will contact you within 24 hours to discuss your requirements.

HOW MUCH IS A CHRONIX BIOMEDICAL BLOOD TEST?

All our tests have the same pricing structure, the first test is £2,000 and any subsequent tests are £1,500. If you have a diagnosis of cancer and are wanting either a second opinion™ or Treatment Outcome Test (Delta Dot) the cost of these tests may be reimbursable on a case by case basis by your medical insurer. Please ask one of our medical team how to proceed with reimbursement applications via your Doctor.

Delta Dot Treatment Outcome Evaluation Test

Delta Dot Treatment Outcome Evaluation Test

The Chronix Biomedical Delta Dot Treatment Outcome Evaluation blood test is a vast improvement over the current methods of determing whether a patient is responding to therapy or not. The essential difference is that now for the first time, due to Next Generation Sequencing we can detect cancer mutations of DNA in blood plasma. Advantages of this new technology, are that we can now look at the entirety of the body relating to cancer. Current scanning and tissue biopsy can only look at a specific part of the body.

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What to do?

1If you have a referral for chemotherapy, immunotherapy or radiation therapy, but you want to ensure the effectiveness of the treatment before using all series of treatments, you should first consult a specialist doctor – oncologist.

You have 3 ways:

  • Use the tips in the ACD partner facility.
  • Immediately contact an authorized ACD doctor. Order the test on our website.
  • Contact your doctor in your medical facility, preferably from ACD authorized doctors list. Your doctor may contact ACD Medical Staff to discuss the test result.

2If you get a referral from your doctor, you should order Delta Dot Treatment Outcome Evaluation Test, and then go for a blood test in one of the ACD authorized laboratories.

3After receiving the first series of treatments, you should repeat the examination Delta Dot.

4Within 7-10 days of the study doctor will get your test results and discuss them with you.

WHAT IS A DELTA DOT TREATMENT OUTCOME EVALUATION TEST?

Chronix Biomedical has now made available a laboratory developed test for monitoring treatment response during the course of therapy. Through the simple process of drawing blood, we can now offer a test that can, with a high degree of accuracy, detect macromolecular mutations of DNA fragments in blood plasma, which can predict whether a patient is responding to therapy.

 

The Chronix Biomedical Delta Dot Treatment Outcome Evaluation blood test is a vast improvement over the current methods of determining whether a patient is responding to therapy or not. The essential difference is that now for the first time, due to Next Generation Genomic Sequencing we can detect cancer mutations of DNA in blood plasma. Advantages of this new technology, also referred to as Liquid Biopsy, is that we can now look at the entirety of the body relating to cancer. Current scanning and tissue biopsy can only look at a specific part of the body.

 

With Chronix Biomedical’s blood test we can now usefully monitor patients by looking at changes in a patient’s Copy Number Imbalance (CNI) score. Blinded studies have shown that when the CNI score does not significantly change over serial sampling, the patient is not responding to therapy. Studies to date have looked at patients with 11 different cancers undergoing radiotherapy, chemotherapy or immunotherapy.

IF MY CHRONIX BLOOD TEST IS POSITIVE WHAT HAPPENS NEXT?

If your blood test comes back with a positive result this result will have been seen by your consulting physician who will explain fully to you the next steps.

WHERE ARE THE CHRONIX BLOOD TESTS DONE?

The blood samples are sent to a certified Chronix Biomedical laboratory in Germany where each sample is whole genome sequenced, we are looking in particular for fragments of mutated DNA that are ejected into the blood plasma, these mutations if seen in large numbers are a fingerprint for cancer.

HOW SOON WILL I RECEIVE THE TEST RESULTS?

Test results will be ready within 7 – 10 days from the date we take your blood, and will sent directly to your Doctor.

ARE CHRONIX BIOMEDICAL TESTS SAFE?

The Chronix blood test consist of our drawing 20ml of blood into two tubes so is minimally invasive and carries no more risk than any other blood sample taken from the veins.

HOW DO I BOOK A CHRONIX BIOMEDICAL BLOOD TEST?

Complete the test enquiry form on our web site here Test Enquiry Form and one of our medical staff will contact you within 24 hours to discuss your requirements.

HOW MUCH IS A CHRONIX BIOMEDICAL BLOOD TEST?

All our tests have the same pricing structure, the first test is £2,000 and any subsequent tests are £1,500. If you have a diagnosis of cancer and are wanting either a second opinion™ or Treatment Outcome Test (Delta Dot) the cost of these tests may be reimbursable on a case by case basis by your medical insurer. Please ask one of our medical team how to proceed with reimbursement applications via your Doctor.

General Health Check

Different outcome scenarios as result of the CNI score

Different outcome scenarios as result of the CNI score